Friday 31 March 2023

US outlets report that a grand jury in New York has voted to indict former president Donald Trump.

Extract from ABC News

Posted 
Donald Trump speaks closely into a microphone with two American flags behind him.
The indictment concerns alleged hush money Donald Trump paid to former adult film actor Stormy Daniels in 2016.(Reuters: Jonathan Ernst)

Donald Trump has been indicted by a Manhattan grand jury after a probe into hush money paid to porn star Stormy Daniels, two sources said on Thursday, becoming the first former US president to face criminal charges, even as he makes another run for the White House.

The charges — arising from an investigation led by Democratic Manhattan District Attorney Alvin Bragg — could reshape the 2024 presidential race.

Mr Trump has previously said he would continue campaigning for the Republican Party's nomination if charged with a crime.

The specific charges are not yet known and the indictment will likely be announced in the coming days.

Mr Trump will have to travel to Manhattan for fingerprinting and other processing at that point.

Susan Necheles — a lawyer representing the former president — said she was informed of the indictment but did not know when Mr Trump would surrender.

A law enforcement source, speaking on condition of anonymity, also confirmed the indictment.

The Manhattan investigation is one of several legal challenges facing Mr Trump, and the charges could hurt his presidential comeback attempt.

Some 44 per cent of Republicans said Mr Trump should drop out of the race if he is indicted, according to recent polling.

The grand jury convened by Mr Bragg in January began hearing evidence about Mr Trump's role in the payment to Stormy Daniels in the days before the 2016 presidential election that he ended up winning.

Ms Daniels — a well-known adult film actress and director whose real name is Stephanie Clifford — has said she received the money in exchange for keeping silent about a sexual encounter she had with Trump in 2006.

The former president's personal lawyer, Michael Cohen, has said that Mr Trump directed hush payments to Ms Daniels and to a second woman, former Playboy model Karen McDougal, who also said she had a sexual relationship with him.

Mr Trump has denied having affairs with either woman.

Federal prosecutors examined the Daniels payoff in 2018, leading to a prison sentence for Cohen but no charges against Mr Trump.

No former or sitting US president has ever faced criminal charges.

Mr Trump also faces two criminal investigations by a special counsel appointed by US Attorney-General Merrick Garland and one by a local prosecutor in Georgia.

Reuters

analysis: Plants can 'talk' and scientists have recorded the sound they make as they die of thirst.

Extract from ABC News

Analysis

By Alice Hayward
Posted 
Budding flower opening, petals are still inside ready to bloom, green leaves all around it
Plants make sounds when they are in distress that can't be detected by human ears.(ABC Sunshine Coast: Annie Gaffney)

If you're like me, you've managed to kill even the hardiest of indoor plants (yes, despite a doctorate in plant biology). But imagine a world where your plants actually told you exactly when they needed watering. This thought, as it turns out, may not be so silly after all.

You might be familiar with the growing body of work that provides evidence for plants being able to sense sounds around them. Now, new research suggests they can also generate airborne sounds in response to stress (such as from drought, or being cut).

A team led by experts at Tel Aviv University has shown tomato and tobacco plants, among others, not only make sounds, but do so loudly enough for other creatures to hear. Their findings, published today in the journal Cell, are helping us tune into the rich acoustic world of plants — one that plays out all round us, yet never quite within human earshot.

Plants can listen, but now they can talk!

Plants are "sessile" organisms. They can't run away from stressors such as herbivores or drought.

Instead, they've evolved complex biochemical responses and the ability to dynamically alter their growth (and regrow body parts) in response to environmental signals including light, gravity, temperature, touch, and volatile chemicals produced by surrounding organisms.

These signals help them maximise their growth and reproductive success, prepare for and resist stress, and form mutually beneficial relationships with other organisms such as fungi and bacteria.

In 2019, researchers showed the buzzing of bees can cause plants to produce sweeter nectar. Others have shown white noise played to a flowering plant in the mustard family can trigger a drought response.

Now, a team led by Lilach Hadany, who also led the aforementioned bee-nectar study, has recorded airborne sounds produced by tomato and tobacco plants, and five other species (grapevine, henbit deadnettle, pincushion cactus, maize and wheat).

These sounds were ultrasonic, in the range of 20-100 kilohertz, and therefore can't be detected by human ears.

A plant with round leaves in a clay pot
Plants are "sessile" organisms meaning they can't run away from stressors such as herbivores or drought.(Wikimedia Commons: Quackor)

Stressed plants chatter more

To carry out their research, the team placed microphones 10cm from plant stems that were either exposed to drought (less than 5 per cent soil moisture) or had been severed near the soil. They then compared the recorded sounds to those of unstressed plants, as well as empty pots, and found stressed plants emitted significantly more sounds than unstressed plants.

In a cool addition to their paper, they also included a soundbite of a recording, down sampled to an audible range and sped up.

The result is a distinguishable "pop" sound.

The number of pops increased as drought stress increased (before starting to decline as the plant dried up). Moreover, the sounds could be detected from a distance of 3-5 metres — suggesting potential for long-range communication.

But what actually causes these sounds?

While this remains unconfirmed, the team's findings suggest that "cavitation" may be at least partially responsible for the sounds. Cavitation is the process through which air bubbles expand and burst inside a plant's water-conducting tissue, or "xylem". This explanation makes sense if we consider that drought stress and cutting will both alter the water dynamics in a plant stem.

Regardless of the mechanism, it seems the sounds produced by stressed plants were informative. Using machine learning algorithms, the researchers could distinguish not only which species produced the sound, but also what type of stress it was suffering from.

It remains to be seen whether and how these sound signals might be involved in plant-to-plant communication or plant-to-environment communication.

The research has so far failed to detect any sounds from the woody stems of woody species (which includes many tree species), although they could detect sounds from non-woody parts of a grapevine (a woody species).

What could it mean for ecology, and us?

It's temping to speculate these airborne sounds could help plants communicate their stress more widely. Could this form of communication help plants, and perhaps wider ecosystems, adapt better to change?

Or perhaps the sounds are used by other organisms to detect a plant's health status. Moths, for example, hear within the ultrasonic range and lay their eggs on leaves, as the researchers point out.

aerial view of green paddock
Could listening to plants help farmers know when commercial crops need irrigating?(Supplied: LAWD)

Then there's the question of whether such findings could help with future food production. The global demand for food will only rise. Tailoring water use to target individual plants or sections of field making the most "noise" could help us more sustainably intensify production and minimise waste.

For me personally, if someone could give a microphone to my neglected veggie patch and have the notifications sent to my phone, that would be much appreciated!

Alice Hayward is a molecular biologist at the University of Queensland and plant molecular physiologist in the Mitter Lab at the Queensland Alliance for Agriculture and Food Innovation. This piece first appeared on The Conversation.

Thursday 30 March 2023

Astronomers detect rare 'ultramassive' black hole, about 33 billion times the mass of the Sun, using gravitational lensing.

Extract from ABC News 

ABC News Homepage

Astronomers detect rare 'ultramassive' black hole, about 33 billion times the mass of the Sun, using gravitational lensing.

Play Video. Duration: 1 minute 52 seconds
This video shows how astronomers used gravitational lensing to discover the black hole.(Supplied: Durham University)

Astronomers making use of a phenomenon known as gravitational lensing have discovered a black hole about 33 billion times the mass of the Sun — close to the upper limit of how large scientists believe they can be.

The rare "ultramassive" black hole sits at the centre of Abell 1201, a supergiant elliptical galaxy residing in a galaxy cluster of the same name, about 2.7 billion light-years from Earth.

Researchers from the United Kingdom's Durham University and Germany's Max Planck Institute discovered the black hole using an innovative technique combining supercomputer simulations with high-resolution pictures taken by the Hubble Space Telescope.

The Hubble pictures showed light from another galaxy behind Abell 1201 was reaching Earth in a way that indicated it was bending around an extremely massive object along the way — creating a 'lensing' effect in which the more distant galaxy was both magnified and seemingly multiplied around a curved edge.

Astronomers believe every large galaxy has a black hole of at least supermassive size (more than 100,000 times the mass of the Sun) at its centre.

The researchers used Durham's DiRAC COSMA8 supercomputer to run hundreds of thousands of simulations of light travelling the same path, each time with a black hole of a different mass in the way.

A grey and pink-tinged starfield has a dark black hole at its centre, around which the light from the stars seems to bend.
An artist's impression of a black hole, where the black hole's intense gravitational field distorts the space around it.(Supplied: ESA/Hubble, Digitized Sky Survey)

When an ultramassive black hole roughly 33 billion times the mass of the Sun was included in the simulations, they produced images that matched the real pictures taken by Hubble.

Dr James Nightingale was lead author of the group's study, which was published in the scientific journal Monthly Notices of the Royal Astronomical Society on Wednesday.

He called the results of the study "extremely exciting", and said the technique the researchers used had implications for future study on distant black holes.

"This particular black hole, which is roughly 30 billion times the mass of our Sun, is one of the biggest ever detected and on the upper limit of how large we believe black holes can theoretically become," he said.

"Most of the biggest black holes that we know about are in an active state, where matter pulled in close to the black hole heats up and releases energy in the form of light, X-rays, and other radiation.

"However, gravitational lensing makes it possible to study inactive black holes, something not currently possible in distant galaxies. This approach could let us detect many more black holes beyond our local universe and reveal how these exotic objects evolved further back in cosmic time."

The discovery of the Abell 1201 ultramassive black hole answers a question first raised almost 20 years ago by another Durham University astronomer, Professor Alastair Edge, who is listed as one of the study's co-authors.

He was reviewing images of a galaxy survey in 2004 when he first noticed the giant arc of a gravitational lens.

Landmark study projects 'dramatic' changes to Southern Ocean by 2050.

Extract from ABC News 

ABC News Homepage

Landmark study projects 'dramatic' changes to Southern Ocean by 2050.

By weather reporter Tyne Logan
Posted 
ice in ocean
Changes to circulation patterns in the Southern Ocean are closely linked to melting ice in Antarctica.(Supplied: Olaf Meynecke)

A "dramatic" change to ocean circulation could unfold in the Southern Ocean over the next three decades with wide-reaching effects on weather and fisheries, according to researchers.

The landmark study, published in Nature on Thursday, examined waters at the deepest layers of the ocean that play a crucial role in circulating heat and nutrients around the globe.

Professor Matthew England said the results were both significant and "concerning", likening their projecting to the premise of The Day After Tomorrow.

The fictional film, which was based on the real-life slowdown of the Atlantic Meridional Overturning Circulation current, saw polar melting disrupt the North Atlantic current, setting off a chain of events that influenced weather around the globe.

"In our simulation, [the slowing circulation] in the Antarctic outpaces the North Atlantic by two to one," Dr England said.

"We know so much about the Atlantic overturning and it's been such an established part of science, so much so that a film has been made about it.

"And here we have an overturning circulation that's just as important to humanity, where we still don't understand why things are changing, what the drivers are, and what the future is."

Freshening the world's densest waters

The findings of the study all have to do with the production of incredibly dense water, formed around Antarctica, known as Antarctic Bottom Water.

Vimeo Australian Academy of Science: "Why are massive ocean currents slowing down?"

The water is essentially the by-product of sea ice formation around Antarctica, which leaves behind very salty and cold water, which can sink to the deepest layers of the ocean.

It is a key part of the conveyer-belt-like system of underwater currents known as the "overturning circulation", which cycle heat, carbon, and nutrients around the globe.

Adele Morrison in computer room
Oceanographer Adele Morrison says the slowing of the Antarctic overturning circulation would have "huge" impacts on marine life.(Supplied: Australian National University)

But oceanographer Adele Morrison, who was one of the authors of the paper, said simulations had shown the overturning circulation would slow down considerably based on a high-emissions scenario.

"By 2050 we're looking at a 40 per cent reduction of the abyssal overturning circulation," Dr Morrison said.

"It's huge. If we shut down this transport of water around the globe, that has a huge impact on lots of things."

Melting ice behind change

Dr Morrison said the slowdown was driven almost exclusively by the melting of ice sheets and shelves.

A large iceberg in in Antarctica
Sea ice formation contributes to the production of Antarctic Bottom Water.(Supplied: Robert Johnson)

"So this puts extra fresh water into the ocean around Antarctica," she said.

"And it's this freshwater that reduces the density and lightens the waters around Antarctica.

"Therefore you don't get as much descending of those dense waters into the abyss, and you get a reduction in the overturning circulation."

Melting of ice around Antarctica is a direct consequence of climate change.

Potential 'collapse' of ecosystems

The overturning currents play a key role in bringing nutrients from the bottom layers of the ocean, where dead marine creatures have sunk to, back toward the surface.

Hundreds of krill crowd around the bottom of an iceberg under the water.
The "overturning circulation" in the Southern Ocean helps move nutrients around the oceans.(Supplied: Alfred-Wegener-Institut; Ulrich Freier/Australian Antarctic Division)

Dr Morrison said slowing the overturning process could have dire consequences for marine life.

"Once you shut down this overturning circulation and its resupply of nutrients, we're looking at danger of collapse of some of these ecosystems," she said.

She said this flow-on effect would play out over a much longer time frame.

"We're studying the dense water formed around Antarctica and its descent into the abyssal ocean," she said.

"But most of the impacts are then felt when the waters rise back up.

"And so the timescales are a bit slower, more sort of century-type timescales."

Impacts to rainfall in the Southern Hemisphere

The overturning circulation also has a relationship with climate patterns.

Dr England said a change in overturning in the ocean could lead to less rainfall in the Southern Hemisphere.

A profile photo of Matthew England
Deputy director of the ARC Australian Centre for Excellence Matthew England said the pace at which the circulation was projected to slow was "dramatic".(Supplied: UNSW)

He said this was driven by a shift in the position of tropical rainbands.

"Overall, the Southern Hemisphere tends to be a bit drier with this overturning slowing down and the Northern Hemisphere tends to get a bit wetter," Dr England said.

Like the impacts to marine life, this would happen over a much longer timescale.

Dr Qian Li, from Massachusetts Institute of Technology, said one of the things that might limit that change was the countering impact of the overturning current in the Northern Hemisphere.

"It depends which magnitude is larger," she said.

The slowdown of circulation could also promote further ice melt around Antarctica, according to the researchers.

Reducing emissions crucial, say researchers

Dr England said without change to emissions, the downward trajectory would continue.

"That 40 per cent value is not where it stops; we only run the simulations to 2050," he said.

"So there's every chance that's going to be 60 per cent or 80 per cent in the decades that follow 2050."

A blue whale and ice berg in the southern ocean
The changes to ocean circulation in the Southern Ocean could have wide-reaching impacts for fisheries.(Supplied: Cath Deacon/Australian Antarctic Division)

Dr England said the importance of reversing the trend should not be underestimated.

"All of human civilisation has developed with this overturning circulation," he said.

"If we switch it off, we fundamentally change the cycling of nutrients through the oceans.

"We could see mass extinction of some species of fish, we could see a loss of fisheries that we rely on for food down the track."

Sweden summons Russia's ambassador over 'legitimate target' statement.

 Extract from ABC News

Posted 
Two tanks seen in snow.
Sweden and Finland have requested to join NATO in the wake of Russia's invasion of Ukraine.(Reuters: Yves Herman)

Sweden said it was summoning the Russian ambassador after he said it and neighbouring Finland would become a "legitimate target" of "retaliatory measures" -- including military ones -- if they join NATO.

The Nordic neighbours ended decades of military non-alignment last May when they decided to join the Atlantic alliance in the wake of Russia's invasion of Ukraine.

Finland and Sweden will become "legitimate targets" of Russian "retaliatory measures" once they join NATO, Russian ambassador Viktor Tatarintsev warned on Tuesday.

But Sweden's Foreign Minister Tobias Billstrom said "the Ministry for Foreign Affairs will summon the Russian ambassador to make a clear statement against this blatant attempt at influence".

"Sweden's security policy is determined by Sweden -- no one else," Mr Billstrom added.

The Russian diplomat upped the ante in the standoff with Stockholm in a statement posted on his embassy's website.

"If anyone still believes that this (NATO membership) in any way will somehow improve Europe's security, you can be sure that the new members of the hostile bloc will become a legitimate target for Russian retaliatory measures, including military ones," he warned.

He said that rather than becoming safer Sweden was "taking a step towards the abyss" by joining NATO.

"After the accession of Finland and Sweden, the total length of the border between Russia and NATO will almost double," he added.

NATO membership requires ratification by all 30 members of the bloc.

After having its bid ratified by Hungary this week, Finland is only waiting on Turkiye, which has signalled it will approve it shortly.

Sweden's bid has meanwhile run into opposition from Hungary and especially Turkiye after a litany of diplomatic spats.

Stockholm still hopes to join before the next NATO summit in Vilnius in July.

AFP

Alexei Navalny's chief of staff says increased economic pressure could push Putin out of office.

Extract from ABC News

ABC News Homepage


Sarah Ferguson and Marina Freri
Posted 
Space to play or pause, M to mute, left and right arrows to seek, up and down arrows for volume.
Play Video. Duration: 8 minutes 6 seconds
Alexei Navalny's chief of staff Leonid Volkov is currently in Australia.(Sarah Ferguson)

The chief of staff for imprisoned Russian opposition leader Alexei Navalny is urging Australia to continue to exert financial pressure on the Kremlin.

"Australia is one of the leading players with regards to the sanction policy," Leonid Volkov told ABC's 7.30.

"And this is important for us … that this sanction policy is tailored to be efficient to split Russian elites and to defeat Putin. That's why we are talking to Australian politicians."

In Australia for meetings in Canberra and with the large Russian diaspora, Mr Volkov said increased economic pressure from the West could make it difficult for Mr Putin to continue to finance his invasion of Ukraine, and ultimately push the dictator out of office.

Since Russia's invasion of Ukraine, Australia has imposed sanctions on Russian oligarchs, as well as on trade and other commercial activity.

"People under pressure, people under stress, tend to make mistakes, and some of these mistakes will be his last," Mr Volkov told 7.30. 

Russian President Vladimir Putin sitting back in his chair during a meeting
Leonid Volkov says increased economic pressure from the West could ultimately push Vladimir Putin out of office.(Reuters: Sputnik)

A life sentence

In August 2020, Mr Navalny was allegedly poisoned by the Russian secret service with a military-grade nerve agent called Novichok. He was flown to Germany for treatment where he remained until January 2021.

Mr Volkov was with Mr Navalny in Germany as he prepared for his fateful return to Moscow, and said the charismatic leader never considered not returning to his homeland.

Russian opposition leader Alexei Navalny looks at a camera while speaking from a prison cell.
From his prison cell, Alexei Navalny heads Russia's opposition movement, the Anti-Corruption Foundation.(AP: Denis Kaminev)

"To stay abroad would be to admit that Putin's strategy to push people he doesn't like out of the country works," he said. 

"What happened to Alexei … that's clearly a life sentence. The question is, for the duration of whose life, Alexei's or Putin's?"

A long-time politician and anti-corruption campaigner, Mr Navalny has been arrested several times on charges varying from fraud to terrorism and extremism.

He always maintained his innocence and rejected all proceedings against him as politically motivated.

Punished for the Oscar-winning documentary

From his cell in a high-security prison about 200 kilometres east of Moscow, Mr Navalny continues to campaign for a post-Putin Russia.

"It's a continuation of the strategy that the Russian government is actually following … to try to break down Alexei psychologically … to make his life in prison unbearable."

According to Mr Volkov, Mr Navalny was moved to a 2x3 metre cell as a form of punishment after the documentary Navalny won an Oscar a few weeks ago.

Navalny Film
A film about the poisoning and imprisonment of Russian opposition leader Alexei Navalny won the Oscar for best documentary.

"He has been put in the punishment cell, which is the most severe punishment within the Russian prison system for the 12th time," Mr Volkov told 7.30.

"We have all the possible reasons to suspect that there is a connection … this is a very small and shitty cell … with a neighbour there who didn't wash himself for the last two months."

Mr Volkov said the harassment of Mr Navalny would not break him, but the nature of his imprisonment endangered his health.

Navalny tweets his policies to the outside world

Mr Navalny communicates with the outside world largely through social media via his lawyers.

Last month, on the first anniversary of the invasion of Ukraine, he outlined a peace plan on Twitter. It included restoring Ukraine's internationally recognised borders.

Mr Navalny's critics said his position on Crimea had been ambiguous in the past, with the politician denouncing Russia's annexation but not campaigning for Crimea's return to Ukraine.

Mr Volkov said Mr Navalny's position is clear.

"We always maintained the position that Crimea was annexed illegally, then we gave a political assessment that, unfortunately, the return to [internationally] recognised borders will not happen soon. And this is just a political reality."

Optimism is part of the job description

Mr Volkov said the Navalny opposition movement would never stop fighting for a democratic alternative to Mr Putin's regime.

Alexei Navalny, a young man in a dark sports jacket, speaks into a microphone
Leonid Volkov says optimism is a job requirement for the opposition movement led by Navalny.(Reuters: Shamil Zhumatov)

"He's not going to give up," Mr Volkov told 7.30.

"Optimism is a job requirement for what we are doing."

He said even in a country where dissidents were persecuted and protests suppressed, it was important to keep speaking up.

"You can't be a Russian opposition politician without a good chunk of optimism …. there are always possibilities to do something," he said.

"And that's our message to everyone … keep fighting."

Watch 7.30, Mondays to Thursdays 7.30pm on ABC iview and ABC TV

Wednesday 29 March 2023

Plastics cause wide-ranging health issues from cancer to birth defects, landmark study finds.

 Extract from The Guardian

A man paddles on a boat as plastic bags float on the water surface of the Buriganga river in Dhaka
Analysis of the impact of plastics found disproportionate effects on coastal and ocean-dependent communities while production workers were at increased risk of a range of diseases.

First analysis of plastics’ hazards over life cycle – from extraction to disposal – also shows ‘deep societal injustices’ of impact.

Wed 29 Mar 2023 01.00 AEDTLast modified on Wed 29 Mar 2023 01.21 AEDT
Plastics are responsible for wide-ranging health impacts including cancers, lung disease and birth defects, according to the first analysis of the health hazards of plastics across their entire life cycle – from extraction for manufacturing, through to dumping into landfill and oceans.

Led by the Boston College Global Observatory on Planetary Health in partnership with Australia’s Minderoo Foundation and the Centre Scientifique de Monaco, the review found “current patterns of plastic production, use, and disposal are not sustainable and are responsible for significant harms to human health … as well as for deep societal injustices”.

“The main driver of these worsening harms is an almost exponential and still accelerating increase in global plastic production,” the analysis, published in the medical journal Annals of Global Health, found. “Plastics’ harms are further magnified by low rates of recovery and recycling and by the long persistence of plastic waste in the environment.”

Coalminers, oil workers and gas field workers who extract fossil carbon feedstocks for plastic production, along with plastic production workers, are at particular risk of harm, the report found.

These workers “suffer increased mortality from traumatic injury … silicosis, cardiovascular disease, chronic obstructive pulmonary disease, and lung cancer,” the report said.

“Plastic production workers are at increased risk of leukaemia, lymphoma … brain cancer, breast cancer, mesothelioma … and decreased fertility. Plastic recycling workers have increased rates of cardiovascular disease, toxic metal poisoning, neuropathy, and lung cancer.”

Meanwhile, residents of communities adjacent to plastic production and waste disposal sites experience increased risks of premature birth, low birth weight, asthma, childhood leukaemia, cardiovascular disease, chronic obstructive pulmonary disease, and lung cancer. The report referred to evidence that infants in the womb and young children are at particularly high risk.

The article recommends a global plastics treaty to control the manufacture and use of plastics, and to reduce the disproportionate health and environmental impacts of plastics on coastal and ocean-dependent communities and those working in high-risk industries. The authors wrote that any treaty should be in accord with the mandate set in March 2022 at the UN Environment Assembly.

Frank Seebacher, a professor in biology at the University of Sydney’s school of life and environmental sciences, agreed that a binding treaty was needed.

“Plastics are on par with climate change in their harmful effects globally, and drive climate change with their need for fossil fuels,” he said.

“The call for better management of plastics is an often-repeated refrain in the literature, particularly because most plastic use is unnecessary – for example, single use plastic and packaging – and can be easily replaced. This new paper looks like it is making a very valuable contribution by synthesising the available literatures into a set of concrete recommendations.”

Group leader of the inflammation biology group at the QIMR Berghofer in Brisbane, Prof Andreas Suhrbier, said nearly all humans now consumed “a fair amount of plastic” and it was crucial that more research funding be dedicated to examining its impact.

“This is estimated at a credit card’s worth of plastic per week, usually in the form of microplastics,” Suhrbier said.

“Sadly, the amount of good medical research in this space is very limited. What are the direct detrimental effects on human health of such plastic consumption? What diseases are exacerbated by such plastic consumption? Who in our population would be most vulnerable?

“Questions regarding the health impacts of microplastic consumption are hard to answer without dedicated research funding and some well-constituted studies that establish a causal relationship between microplastic consumption and a disease or disorder.”